I'm not sure what destination would be my perfect vacation. I've been to many big cities--Chicago, New York, Vegas, Los Angeles, Houston...and while they are fun for a few days, I always come back more tired than when I left. This is probably true for those coming back from any vacation. You spend all your time trying to cram in all sights and activities in approximately one week, give or take a few travel days/hours and you are left exhausted. I'm not sure that visiting a big city could constitute a vacation for me...maybe just a get away.
Although I'm in need of a vacation, I don't know where I would go...I'm going to have to think about this for awhile.